Tabell 1: Legemidler som metaboliseres av eller som hemmer ulike cytokrom P450 (CYP)-enzymer i leveren

agomelatin, anagrelid, asenapin, bendamustin, duloksetin, klozapin, koffein, leflunomid^a, loksapin, meksiletin, melatonin, olanzapin, pirfenidon, pomalidomid, rasagilin, riluzol, roflumilast, ropinirol, ropivakain, tasimelteon, teofyllin, tizanidin, zolmitriptan

Sterke hemmere:
fluvoksamin, givosiran, kapmatinib, ritlecitinib, vemurafenib

Moderate hemmere:
metoksalen

alfentanil, artemisinin, bupropion, efavirenz, ifosfamid, ketamin, metadon, nevirapin, propofol, selegilin, syklofosfamid^a, tramadol^a

Moderate hemmere:
klopidogrel, tiklopidin

amiodaron, dasabuvir, enzalutamid, klorokin, montelukast, paklitaxel, pioglitazon, repaglinid, tukatinib, seleksipag

Sterke hemmere:
gemfibrozil, klopidogrel, teriflunomid

Moderate hemmere:
deferasiroks, linzagoliks, selperkatinib

afikamten, avatrombopag, celekoksib, fenytoin, fluvastatin, fosfenytoin, glibenklamid, glimepirid, glipizid, ibuprofen, irbesartan, lesinurad, losartan^a, meloksikam, mikonazol, nateglinid, piroksikam, rosuvastatin, seladepar, siponimod, tetrahydrocannabinol, torasemid, warfarin

Moderate hemmere:
amiodaron, flukonazol

amitriptylin, brivaracetam, celekoksib, citalopram, diazepam, escitalopram, esomeprazol, karisoprodol, klobazam^d, klomipramin, klopidogrel^a, lansoprazol, moklobemid, omeprazol, pantoprazol, proguanil^a, propranolol, rosiglitazon, sertralin, sulfametoksazol, vorikonazol

Sterke hemmere:
flukonazol, fluvoksamin, tiklopidin

Moderate hemmere:
esomeprazol, moklobemid, omeprazol, vorikonazol

amitriptylin, aripiprazol, atomoksetin, brekspiprazol, darifenacin, doksepin, donepezil, eliglustat, fesoterodin, flekainid, fluoksetin, fluvoksamin, haloperidol, hydrokodon, karvedilol, klomipramin, kodein^a, meksiletin, metoprolol, mianserin, nortriptylin, ondansetron, palonosetron, paroksetin, perfenazin, risperidon, sertindol, tamoksifen^a, tetrabenazin, timolol, tolterodin, tramadol^a, tropisetron, venlafaksin, vortioksetin, zuklopentiksol

Sterke hemmere:
bupropion, cinacalcet, fluoksetin, paroksetin, terbinafin

Moderate hemmere:
abirateron, duloksetin, mirabegron, dakomitinib

A-B aksitinib, alfentanil, alfuzosin, alprazolam, amiodaron, amlodipin, amprenavir, apremilast, aprepitant, aripiprazol, atazanavir, atorvastatin, avanafil, avatrombopag, bedakvilin, biktegravir, bortezomib, bosentan, bosutinib, bromokriptin, brekspiprazol, budesonid, buprenorfin, buspiron

C-D cannabidiol, ceritinib, ciklesonid, ciklosporin, cinacalcet, daklatasvir, dabrafenib, darifenacin, darunavir, dasatinib, deksametason, dienogest, diltiazem, docetaxel, dronedaron, dutasterid

E-F ebastin, elbasvir, eletriptan, eliglustat, eplerenon, ergotamin, erlotinib, erytromycin, eszopiklon, etinyløstradiol, etravirin, everolimus, fedratinib, felodipin, fentanyl, fesoterodin, flutikason, fosamprenavir, fostemsavir

G-J gefitinib, gilteritinib, grazoprevir, guanfacin, haloperidol, ibrutinib, imatinib, imlunestrant, indinavir, irinotekan, isradipin, itrakonazol, ivabradin, ivakaftor

K-L kabazitaxel, kabergolin, kabozantinib, karbamazepin, kariprazin, ketamin, ketokonazol, klaritromycin, klobazam, kobimetinib, kolkisin, krizotinib, kvetiapin, lapatinib, lazertinib, lerkanidipin, lomitapid, loperamid, lopinavir, loratadin, lovastatin, lurasidon

M-N maraviroc, metadon, metylprednisolon, midazolam, midostaurin, naloksegol, nelfinavir, nevirapin, nifedipin, nilotinib, nimodipin

O-Q oksybutynin, oksykodon, osimertinib, paklitaxel, palbociklib, panobinostat, pazopanib, posakonazol, prednisolon, prednison^a

R-S ranolazin, reboksetin, regorafenib, ribosiklib, rifampicin, rilpivirin, rilzabrutinib, riociguat, risperidon, ritonavir, rolapitant, ruxolitinib, sakinavir, saksagliptin, salmeterol, selperkatinib, sertindol, sertralin, sildenafil, simeprevir, simvastatin, sirolimus, solifenacin, sonidegib, stiripentol, sunitinib

T-U tadalafil, takrolimus, tamsulosin, telaprevir, temsirolimus, ticagrelor, tipranavir, tolvaptan, toremifen, trabektedin, ulipristal, upadacitinib

V-W vandetanib, vardenafil, venetoklaks, verapamil, vinblastin, vinflunin, vinkristin, vinorelbin, voksilaprevir, vorapaksar, vorikonazol

X-Z ziprasidon, zolpidem, zopiklon

Sterke hemmere:
adagrasib, atazanavir, boceprevir, ceritinib, idelalisib, indinavir, itrakonazol, ketokonazol, klaritromycin, kobicistat, lonafarnib, posakonazol, ritonavir, telaprevir, vorikonazol

Moderate hemmere:
aprepitant^b, diltiazem, dronedaron, duvelisib, erytromycin, fedratinib, flukonazol^c, grapefruktjuice, krizotinib, lenakapavir, netupitant, nilotinib, ribosiklib, tukatinib, verapamil